to destroy completely: to wipe out a people, place, or thing so that nothing remains
The word describes total, irreversible destruction, not damage, defeat, or exile, but the complete elimination of something from existence. When peoples are destroyed, their presence is erased from the land. When cultic objects or high places are destroyed, they are brought to ruin so they can no longer function. The word carries a finality that most synonyms lack.
It is used most heavily in Deuteronomy, both as a warning of what God will do to Israel's enemies and as a covenant curse against Israel itself if it abandons its commitments. The two grammatical voices, active (bringing about destruction) and passive (undergoing it), describe two sides of the same event: an agent who acts and a recipient who ceases to exist.