to destroy: to put to death or bring to ruin so that something or someone is wiped out
When the word is used of one person or power acting on another, it means to do away with them: to kill, to wreck, to finish off. The force is total. It is not merely to harm or weaken but to bring to an end.
The range runs from ordinary violence (plotting to kill Jesus, a king destroying murderers) to God's final judgment, where the same word names the ruin of both body and life in the age to come. The thread holding these together is one agent deliberately bringing about the end of another.
The New Testament also turns this around as a warning: clinging to your life destroys it, while losing it for Jesus saves it. The destroyer there is the person's own grasping.