distress: the experience of being in a tight, threatening place, whether outward danger or inner anguish
This is the Bible's common word for being in deep trouble. It pictures a person hemmed in, pressed, squeezed into a narrow place, and from that picture it covers the whole range of hard straits a person or nation can fall into: war, siege, disaster, sickness, persecution, and the fear and grief that come with them.
The word holds together two sides of the same experience that English often keeps apart. It can name the outward situation, the danger or calamity itself, as in the repeated cry to God in the day of trouble. And it can name the inward feeling, the anguish and anxiety a person carries, as when the heart is in distress. The two are rarely far apart, because the trouble outside is felt as anguish inside.
Because of that cornered, pressing sense, the prophets often reach for it to describe pain so sharp it is compared to a woman in labor: gripping, unavoidable, and beyond the sufferer's control. It is also the word at the heart of many psalms of lament, where the worshiper names the trouble plainly and then calls on God to bring rescue out of it.