to work one's will on a person: to deal harshly with them, to make sport of or abuse them
This verb pictures a stronger party working its will on someone weaker, treating the other as an object to be dealt with however the actor pleases. The tone is set entirely by who is acting and why. When God is the actor, English Bibles reach for "afflict" or "deal severely with," as in the poems of Lamentations, where Jerusalem cries that the Lord has dealt harshly with her.
When a person is the actor, the verb turns cruel and often contemptuous. It covers making a fool of someone (Balaam complains that his donkey has made sport of him), one nation mocking another (as Egypt was mocked in the exodus), and at its darkest the violent abuse of a helpless victim (the horror of Judges 19). The same word can also fold back on the actor, describing a person who busies himself with wicked deeds.
What holds these uses together is not a fixed moral color but a fixed relationship: one side imposes, the other is imposed upon. It sits close to ענה, the ordinary word for afflicting or humbling, but leans harder toward wanton, willful treatment than toward simple oppression.