to commit adultery: to break a marriage by sexual unfaithfulness to one's spouse.
The word names one specific act: breaking a marriage by giving to someone else what belongs to one's husband or wife. It is narrower than the general word for sexual immorality (πορνεύω), which covers illicit sex of any kind. Adultery is the betrayal of a marriage in particular, and it stands as the seventh of the Ten Commandments, cited again and again in the New Testament as shorthand for covenant-breaking.
Jesus stretches the word in two directions without changing what it means. He moves it inward, so that a lustful look has "already" committed adultery in the heart (Matthew 5:28), and he applies it to divorce and remarriage, calling the new union adultery against the first (Luke 16:18). In both cases the act is still adultery; Jesus simply refuses to let it stay on the surface of outward behavior.
Scripture also turns the word toward God. In Revelation 2:22 those who follow the false prophet "Jezebel" are said to commit adultery with her, echoing the Old Testament prophets who pictured Israel's idolatry as a betrayed marriage. The nearest Hebrew word (נָאַף) lives the same double life, naming both a broken marriage and a people unfaithful to their God.