The lexicographical tradition is unanimous on the core sense: the word denotes the state or act of drunkenness, episodic intoxication rather than habitual alcoholism. LSJ groups three classical senses (the intoxicating drink itself in older poetry, e.g. Herodotus 5.20 and Sophocles OT 779; the state of drunkenness, Plato Rep. 363d, Laws 674a, 775b; and in the plural drinking-bouts or carousals, Plato Laws 682e, Judith 13:15, Rom 13:13). BDAG (3rd ed., 625–626) glosses the singular "state of intoxication, drunkenness" and the plural "drinking-bouts, carousing"; Louw-Nida places it at 88.285, "the state of intoxication," distinguished from μέθυσος (88.286, the intoxicated person) and οἰνοφλυγία (88.287, the state of being habitually drunk). The noun is a back-formation from μεθύω, itself built on the Homeric μέθυ ("intoxicating drink," cognate with Sanskrit madhu and Old English medu). Preisker (TDNT 4:545–548) and Spicq trace the group from Homer through the classical moralists, where Plato is famously ambivalent (defending controlled μέθη within the symposium at Laws 637a–b and 666a–674c, mocking μέθη αἰώνιος at Rep. 363d) and Aristotle is not (Nic. Eth. 3.1113b30–1114a3 on double culpability; οἰνοφλυγία among the vices at 3.5), and into the documentary papyri (P.Hal. 1.193; BGU IV.1024), where drunkenness figures as a routine social and legal category. Trench, Synonyms §lxi, established the distinction still followed by BDAG, Louw-Nida, and NIDNTTE: μέθη is the drinking and intoxication, κῶμος the revel that traditionally followed it.
In the Septuagint the word-group renders chiefly שֵׁכָר, שִׁכָּרוֹן, שָׁכַר, and רָוָה, with μέθη itself appearing roughly 24 times; the evaluation is uniformly negative (Gen 9:21; Isa 5:11, 22; 28:1–8; Ezek 23:33; Jer 13:13; Prov 20:1; 23:29–35; Sir 31:25–31, the balanced Second Temple summary that wine in moderation is the life of man but wine drunk ἐν μέθῃ is ruin). The cup-of-wrath strand (Ps 60:5 [LXX 59:5]; Isa 51:17–23; Jer 25:15–29; Ezek 23; Hab 2:16; Jer 51:7 LXX) supplies the imagery reused in Rev 14:10; 16:19; 17:2, 6, as Preisker, Silva's NIDNTTE, and the Revelation commentators (Aune WBC, Beale NIGTC, Koester AYB, Osborne BECNT, Boxall BNTC) all note.
On Luke 21:34 Green (NICNT), Nolland (WBC), Bovon (Hermeneia), Bock (BECNT), Marshall (NIGTC), and Fitzmyer (AB) converge: κραιπάλη (a NT hapax, well attested in Aristophanes and Hippocrates for the drinking-bout and its hangover) plus μέθη plus μέριμναι βιωτικαί make drunkenness the paradigm of unpreparedness for the day, with the παγίς of v. 35 alluding to Isa 24:17 and the dulled heart recalling Isa 6:10. In the two Pauline occurrences the noun is plural, and virtually every major commentator reads the plural as iterative or intensive: Cranfield (ICC 2:688) takes each pair in Rom 13:13 as "one composite idea" and notes that the plural "suggests frequent repetition," with Dunn (WBC), Moo (NICNT), Longenecker (NIGTC), and Schreiner (BECNT) agreeing, while Jewett (Hermeneia) reads the three pairs as a coherent convivium scenario running from drinking-party to street procession to sexual license to violent rivalry, framed by the eschatological contrast of 13:11–12. On Gal 5:21 Betz (Hermeneia) classifies the catalogue as a traditional Hellenistic-Jewish Lasterkatalog with parallels in Philo, Wisdom, 4 Maccabees, and the Testaments of the Twelve Patriarchs; Bruce (NIGTC) glosses μέθαι "drunken bouts"; Longenecker (WBC) files both terms under vices of intemperance; Martyn (AB) reads the list as diagnostic of the cosmic power of the Flesh without disputing the lexical sense, and the participle πράσσοντες carries the force of habitual practice. Across the paraenetic material the word stands in fixed opposition to νήφω, which Malherbe, Best, Achtemeier, and Elliott read as a metaphor for eschatological watchfulness drawn simultaneously from Jewish apocalyptic and Hellenistic moral philosophy. Philo's coinage μέθη νηφάλιος (Ebr. 146–149), traced by Lewy in Sobria Ebrietas, shows how readily ecstatic experience and intoxication were assimilated in Hellenistic Jewish thought, the datum behind the charge of Acts 2:13 and the antithesis of Eph 5:18.