badly off in body: sick, suffering severely, or brought to a wretched end
This is the ordinary Greek adverb for "badly", and the Gospel writers use it most often about bodies. Joined to the verb "to have", it makes the common phrase for being ill, which reads literally as "having badly". The phrase names no disease and offers no diagnosis. It says only that a person is doing badly, and the surrounding words supply the details: a fever, a lifelong disability, or a servant close to death.
Because the word measures how bad something is rather than what it is, it also works as a plain intensifier. In two of Matthew's healing stories it stretches an affliction to its worst: a daughter is not merely troubled by a spirit but badly troubled, and a boy does not merely suffer but suffers badly.
One use turns the same word back on people rather than on their bodies. In the parable of the vineyard the tenants pronounce their own sentence: bad men, and they will come to a bad end. Greek liked that pairing of the adjective with its adverb, and the effect is a grim rhyme rather than a legal verdict.
Almost every occurrence sits in the healing summaries of Matthew, Mark and Luke, in the lines where crowds carry "all who were doing badly" to Jesus. That is why the word feels medical in English, though the Greek itself is entirely plain.